guanosine monophosphate solubility

Water Solubility: 15.3 mg/mL: ALOGPS: logP-2.1: ALOGPS: logP-2.7: ChemAxon: logS-1.3: ALOGPS: pKa (Strongest Acidic) 10.16: ChemAxon: pKa (Strongest Basic) 0.45: The relationship between the subcellular distribution of guanylate cyclase and tissue guanosine-3',5'-cyclic monophosphate (cGMP) levels was investigated in rat testes after surgically PDE-5 converts the Our results support the possibility of a soluble interaction between N2,O2'-dibutyryl cyclic guanosine 3':5'-monophosphate and the peptides of cholecystokinin-gastrin family that is The soluble enzyme can utilize MnGTP (Km = 55 micrometer), MgGTP (Km = 310 micrometer) and CaGTP (Km greater than 500 micrometer) as substrates. View substitute products. Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It is very 20C. Other strategies to increase tissue cyclic guanosine monophosphate have been attempted, such as PDE-3 or PDE-5 inhibition (with negative or neutral results), NO-independent soluble guanylate cyclase (sGC) activation, or enhancement of sGC sensitivity to endogenous NO. Solubility Information: Solubility in water: >50g/l water: Formula Weight: 407.19: Physical Form: Crystalline Powder: Percent Purity: 97%: Based on Yamaokas report , cyclic guanosine 5-monophosphate: GDP: guanosine 5-diphosphate: dGDP: deoxyguanosine 5-diphosphate: GTP: guanosine 5-triphosphate: dGTP: Cyclic guanosine monophosphate (cGMP) Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). GMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase guanine; hence it is a ribonucleoside monophosphate. (lambda max. Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its most likely mechanism of action is activation of intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface. Introduction: Kidney fibrosis has shown to be ameliorated through the involvement of cyclic guanosine monophosphate (cGMP) and its dependent protein kinase I (cGKI). Please call customer service for assistance: 1-800-766-7000. Product Description. Disodium guanylate is a food additive with the E number E627. Despite advances in treatments and improved survival, patients with pulmonary hypertension still experience poor exercise and functional capacity, which has a significant Guanosine 5'-monophosphate is a nucleotide used in the synthesis of RNA. Most (about 85%) of the guanylate cyclase activity of broken-cell preparations is found in the soluble fraction. Appleman MM. The second messenger cGMP participates in Guanosine possesses anti- HSV activity. Except where otherwise noted, data are given for materials in their standard state (at 25 C [77 F], 100 kPa). ?) Guanosine monophosphate ( GMP ), also known as 5-guanidylic acid or guanylic acid ( conjugate base guanylate ), is a nucleotide that is used as a monomer in RNA. Identification Generic Name Guanosine-5'-Monophosphate DrugBank Accession Number DB01972 Background. 5g; Glass bottle. Guanosine-5'-monophosphate PubChem CID 135398631 Structure Find Similar Structures Molecular Formula C10H14N5O8P Synonyms 5'-Guanylic acid guanosine monophosphate Molecular Weight 363.22 2 more rows Guanosine 5-monophosphate is suitable for use in: the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, Guanosine is a white, crystalline powder with no odor and mild saline taste. It is very soluble in acetic acid, slightly soluble in water, insoluble in ethanol, diethyl ether, benzene and chloroform. 252nm,pH 7) molar absorptivity 13700+/-4%,pH 7: Formula Weight: 407.19: Physical On the specification sheets of the products, it is written they are soluble in HCl. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a -N9-glycosidic bond. Serelaxin, the recombinant form of human relaxin-II, increases cGMP levels and has shown beneficial effects on kidney function in acute heart failure patients. It Product Description. Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate Peptide hormones such as the atrial natriuretic factor activate membrane Moreover, guanine is a white amorphous solid, while guanosine is a white crystalline powder. Disodium guanylate, also known as sodium 5'-guanylate and disodium 5'-guanylate, is a natural sodium salt of the flavor enhancing nucleotide guanosine monophosphate (GMP). It is commonly used in conjunction with glutamic acid (monosodium glutamate, MSG). Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosp Protocol (from reference) Molecular weight : 407.19 Guanosine-5'-Monophosphate Molecular Formula : C 10 H 12 N 5 Na 2 O 8 P 2-8C See Also: plantmedia.com biolabprotocols.com antibodydirectory.com chemicalsfinder.com biokits.com enzymedirectory.com . They are soluble in water and sparingly in alcohols but not in ethers. It is known as E number reference E626. This item has been discontinued by the manufacturer and is no longer available. Guanosine monophosphate is commercially produced by microbial fermentation. Biochem/physiol Actions. CAS. Is guanosine a nucleic acid? The acetate salt form of dibutylamine was selected because it has better solubility in water. Guanylyl cyclases (GCs) are enzymes that convert guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophosphate (cGMP). water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless. Solubility of Guanosine-5'-Monophosphate : Soluble in water. Guanosine monophosphate is commercially produced by microbial fermentation. Guanosine monophosphate (GMP), also known as 5-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer in RNA. Guanosine 5'-monophosphate. In a rat model of liver cirrhosis phosphodiesterase-5 (PDE-5) was markedly overexpressed both on the mRNA and the protein level. 2. Guanosine 5-monophosphate is suitable for use in: the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, Guanosine 3,5-cyclic monophosphate sodium salt (cGMP ); >= 99% HPLC, powder; This compound is a featured product for Cyclic Nucleotide research; An important second Only cytosine dissolve at 55C but precipitate again when the temperature goes down. Shop a large selection of Organooxygen compounds products and learn more about Guanosine 5'-monophosphate, disodium salt hydrate, 97%, ACROS Organics. Molecular Formula. 5'-Ribonucleotide products, Disodium Inosine-5'-monophosphate (IMP), Disodium-5'-guanosine monophosphate (GMP) and their mixture (I+G), are white crystals or crystalline powder. solubility. storage temp. C 10 H A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. Upon phosphorylation to GTP, it becomes incorporated into RNA by various RNA polymerases. Core tip: A constriction of sinusoids plays an important role in the pathogenesis of cirrhotic portal hypertension, wherein the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway plays a pivotal role. Guanosine is a white, crystalline powder with no odor and mild saline taste. The key difference between guanine and guanosine is that guanine is a nucleobase, whereas guanosine is a nucleoside. It is an ester of phosphoric acid with the nucleoside guanosine. Mfr: Thermo Scientific Chemicals 226601000. 1 It can be used to study modulation of glutamatergic neurotransmission. One of the most widely studied and best-understood NO second messenger systems is the activation of soluble guanylate cyclase (sGC) and the subsequent generation of intracellular 3,5-cyclic guanosine monophosphate (cGMP) [12, 13]. It modulates glutamate uptake by glutamate transporters. 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